Cytokine and Chemokine mRNA Expressions after Mycobacterium tuberculosis-Specific Antigen Stimulation in Whole Blood from Hemodialysis Patients with Latent Tuberculosis Infection

There have been few reports on the kinetics of hemodialyzed (HD) patients’ immune responses in latent tuberculosis infection (LTBI). Therefore, present study, messenger ribonucleic acid (mRNA) expression levels nine markers were analyzed to discriminate between HD patients with LTBI and healthy individuals. Nine cytokines chemokines screened through relative mRNA whole blood samples after stimulation Mycobacterium (MTB)-specific antigens from (HD/LTBI), without LTBI, individuals, results compared QuantiFERON-TB Gold In-Tube (QFT-GIT) test. We confirmed that C-C motif chemokine 11 (CCL11) level HD/LTBI group was significantly higher than other two groups. Especially, CCL11 >0.7 IU/mL QFT-GIT test <0.2 0.2–0.7 (p = 0.0043). The study reveals statistically different based current cut-off value (i.e., ≥0.35 IU/mL) group. These suggest might be an alternative biomarker for diagnosis patients.